The INI-CET syllabus is based on the MBBS curriculum prescribed by the Medical Council of India. It covers subjects like Anatomy, Physiology, Biochemistry, Pathology, Pharmacology, Microbiology, Forensic Medicine, Community Medicine, Ophthalmology, ENT, Medicine, Surgery, Obstetrics & Gynecology, Pediatrics, and Preventive & Social Medicine. Clinical knowledge and problem-solving ability are heavily emphasized.