Biomedical engineering (BME) is use of engineering principles and design concepts into medicine and biology for healthcare purposes. This field seeks to lessen the gap between engineering and medicine to advance health care treatment, including diagnosis, monitoring, and therapy. Biomedical engineering applications include the development of biocompatible prostheses, various diagnostic and therapeutic medical devices, clinical equipment, micro-implants, common imaging equipment such as MRIs and EEGs, regenerative tissue growth, pharmaceutical drugs and therapeutic biologicals. Tissue engineering (like genetic engineering) , is a major segment of biotechnology - which overlaps significantly with BME. Genetic engineering, recombinant DNA technology, genetic modification/manipulation (GM) and gene splicing are ways to direct manipulation of an organism's genes. Neural engineering (or neuroengineering) is a discipline that makes use of engineering techniques to understand, repair, replace, or enhance neural systems. Pharmaceutical engineering involves drug engineering, novel drug delivery and targeting, pharmaceutical technology etc. Biomedical Engineering is a broad category which covers all health care products that do not achieve their intended results through chemical or biological means and do not involve metabolism. Examples are pacemakers, infusion pumps, the heart-lung machine, dialysis machines, artificial organs, implants, artificial limbs, corrective lenses, cochlear implants, ocular prosthetics, facial prosthetics, somato prosthetics, and dental implants.